陈阳，1979年生，基础医学研究所院研究员，博士生导师。1998-2002年在中山大学药学专业、计算机辅修专业学习，获学士学位。2002-2005年在中国协和医科大学医学生物学研究所免疫学专业学习，获硕士学位。2005-2008年在中国协和医科大学医学生物学研究所生物化学与分子生物专业学习，获博士学位。2008-2011年在清华大学自动化系控制科学与工程博士后站进行博士后研究。 2011-2019年在清华大学信息国家研究中心任职助理研究员、副研究员，主要从事基因组与生物信息学研究。

主要围绕疾病的基因组学基础开展下列三个方面研究：开发新一代时空组学技术与生物信息学方法；解析疾病中的基因组调控规律；开展疾病个体化预防、诊疗新策略研究。

1. Ruiting Wang#, Fengling Chen#, Qian Chen#, Xin Wan#, Minglei Shi, Antony K. Chen, Zhao Ma, Guohong Li, Min Wang, Yachen Ying, Qinyao Liu, Hu Li, Xu Zhang, Jinbiao Ma, Jiayun Zhong, Meihong Chen, Michael Q. Zhang*, Yong Zhang*, Yang Chen*, Dahai Zhu*. MyoD is a 3D genome structure organizer for muscle cell identity. Nature Communications, 2022, 13:205. (IF=17.694)

2. Zhiyuan Yuan#, Qiming Zhou#, Lesi Cai#, Lin Pan, Weiliang Sun, Shiwei Qumu , Si Yu, Jiaxin Feng, Hansen Zhao, Yongchang Zheng, Minglei Shi, Shao Li, Yang Chen*,  Xinrong Zhang*, Michael Q. Zhang*. SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment. Nature Methods, 2021, 18(10):1223-1232. (IF=47.990)

3. Minglei Shi#*, Kaiqiang You#, Taoyu Chen, Chao Hou, Zhengyu Liang, Mingwei Liu, Jifeng Wang, Taotao Wei, Jun Qin, Yang Chen*, Michael Q Zhang*, Tingting Li*. Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index. Genome Biology, 2021, 22:229. (IF=17.906)

4.Shuai Jiang, Hao Li, Hao Hong, Guifang Du, Xin Huang, Yu Sun, Junting Wang, Huan Tao, Kang Xu, Cheng Li, Yang Chen*, Hebing Chen*, Xiaochen Bo*. Spatial density of open chromatin: an effective metric for the functional characterization of topologically associated domains. Briefings in Bioinformatics, 2021, 22(3):bbaa210. (IF=13.994)

5. Kaiqiang You#, Qi Huang#, Chunyu Yu#, Boyan Shen, Cristoffer Sevilla, MingleiShi, HenningHermjakob*, Yang Chen*, Tingting Li*. PhaSepDB: a database of liquid–liquid phase separation related proteins. Nucleic Acids Research, 2020, 48(D1):D354-D359. (IF=19.160, F1000)

6. Fengling Chen#, Guipeng Li#, Michael Q Zhang, Yang Chen*.HiCDB :a sensitive and robust method for detecting contact domain boundaries. Nucleic Acids Research, 2018, 46:11239-11250. (IF=19.160)

7. Mohamed Nadhir Djekidel#, Yang Chen*, Michael Q. Zhang*. FIND : difFerential chromatin INteractions Detection using a spatial Poisson process. Genome Research, 2018, 28:1-11. (IF=9.438)

8. Zhengyu Liang, Guipeng Li, Zejun Wang, Mohamed Nadhir Djekidel, Yanjian Li, Minping Qian, Michael Q. Zhang* and Yang Chen*. BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions. Nature Communications, 2017, 8:1622. (IF=17.694)

9. Jingyu Wang, Fengling Chen, Longwei Liu, Chunxiao Qi, Bingjie Wang, Xiaojun Yan, Chenyu Huang, Wei Hou, Michael Q. Zhang, Yang Chen*, Yanan Du*. Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation. Biomaterials, 2016, 91:11-22. (IF=15.304)

10. Mohamed Nadhir Djekidel, Zhengyu Liang, Qi Wang, Zhirui Hu, Guipeng Li, Yang Chen*, Michael Q. Zhang*. 3CPET: finding co-factor complexes from ChIA-PET data using a hierarchical Dirichlet process. Genome Biology, 2015, 16:288. (IF=17.906)